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LI Qiang, XIE Shun, ZENG Songqing, LI Jie, XU Youfa, ZHANG Shen, HUANG Xianhui. Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits[J]. Journal of South China Agricultural University, 2017, 38(2): 18-21. DOI: 10.7671/j.issn.1001-411X.2017.02.004
Citation: LI Qiang, XIE Shun, ZENG Songqing, LI Jie, XU Youfa, ZHANG Shen, HUANG Xianhui. Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits[J]. Journal of South China Agricultural University, 2017, 38(2): 18-21. DOI: 10.7671/j.issn.1001-411X.2017.02.004

Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits

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  • Received Date: April 28, 2016
  • Available Online: May 17, 2023
  • Objective 

    To investigate the pharmacokinetics and bioavailability after oral administration of the coccidiostat, robenidine hydrochloride in rabbits.

    Method 

    A total of 16 healthy New Zealand white rabbits were allotted to two groups and received single intravenous administration of robenidine hydrochloride at the dose of 2.00 mg·kg-1 and single oral administration at the dose of 100.00 mg·kg-1 respectively. Blood samples were collected and analyzed by high-performance liquid chromatography (HPLC) using UV. Pharmacokinetic parameters were estimated using the WinnonlinTM software package and the curve of time and concentration was obtained using SPSS 16.0.

    Result 

    After i.v. injection, area under the concentration-time curve (AUC) was 1.72 μg·h·mL-1, plasma clearance (CI) was 1.17 L·h-1·kg-1, the volume of distribution was 2.87 L·kg-1 and the half-life of elimination (t1/2) was 1.72 h. After oral administration, t1/2 was 8.94 h and AUC was 6.33 μg·h·mL-1. Statistical analysis showed that there were significant differences between pharmacokinetic parameters of intravenous and oral administration (P < 0.05), and the bioavailability following oral administration was low (7.36%).

    Conclusion 

    The volume of distribution following robenidine hydrochloride was high, suggesting that the drug was widely distributed in rabbits and eliminated rapidly; Robenidine hydrochloride for oral administration was rarely absorbed into the blood or blood circulation, and the residues in vivo was low.

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