Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits

LI Qiang; XIE Shun; ZENG Songqing; LI Jie; XU Youfa; ZHANG Shen; HUANG Xianhui

doi:10.7671/j.issn.1001-411X.2017.02.004

Journal of South China Agricultural University > 2017 > 38(2): 18-21. > DOI: 10.7671/j.issn.1001-411X.2017.02.004

LI Qiang, XIE Shun, ZENG Songqing, LI Jie, XU Youfa, ZHANG Shen, HUANG Xianhui. Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits[J]. Journal of South China Agricultural University, 2017, 38(2): 18-21. DOI: 10.7671/j.issn.1001-411X.2017.02.004

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Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits

College of Veterinary Medicine/National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou 510642, China

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Received Date: April 28, 2016
Available Online: May 17, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the pharmacokinetics and bioavailability after oral administration of the coccidiostat, robenidine hydrochloride in rabbits.
Method
A total of 16 healthy New Zealand white rabbits were allotted to two groups and received single intravenous administration of robenidine hydrochloride at the dose of 2.00 mg·kg^-1 and single oral administration at the dose of 100.00 mg·kg^-1 respectively. Blood samples were collected and analyzed by high-performance liquid chromatography (HPLC) using UV. Pharmacokinetic parameters were estimated using the Winnonlin^TM software package and the curve of time and concentration was obtained using SPSS 16.0.
Result
After i.v. injection, area under the concentration-time curve (AUC) was 1.72 μg·h·mL^-1, plasma clearance (CI) was 1.17 L·h^-1·kg^-1, the volume of distribution was 2.87 L·kg^-1 and the half-life of elimination (t_1/2) was 1.72 h. After oral administration, t_1/2 was 8.94 h and AUC was 6.33 μg·h·mL^-1. Statistical analysis showed that there were significant differences between pharmacokinetic parameters of intravenous and oral administration (P < 0.05), and the bioavailability following oral administration was low (7.36%).
Conclusion
The volume of distribution following robenidine hydrochloride was high, suggesting that the drug was widely distributed in rabbits and eliminated rapidly; Robenidine hydrochloride for oral administration was rarely absorbed into the blood or blood circulation, and the residues in vivo was low.
- robenidine hydrochloride,
- pharmacokinetic,
- bioavailability,
- rabbit

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References (13)

References

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Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits