- Chinese Core Journal
- Chinese Science Citation Database (CSCD) Source journal
- Journal of Citation Report of Chinese S&T Journals (Core Edition)
| Citation: |
YANG Dexue, CHEN Liangzhu, LAI Lihong, REN Miaoxian, ZHANG Guijun, PAN Zhikun, FANG Binghu. Research on pharmacokinetics and bioavailability of pleuromutilin derivative BC-7013 in chickens[J]. Journal of South China Agricultural University, 2015, 36(4): 26-31. DOI: 10.7671/j.issn.1001-411X.2015.04.005
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The pharmacokinetical characteristics and bioavailability of pleuromutilin derivative BC-7013 in chickens were investigated.
Twenty chickens were randomly divided into two groups for pharmacokinelical experiments after a single intravenous(2.5 mg·kg-1) and oral administra tion(15 mg·kg-1).Blood samples were collected at different intervals after the administration of deriv ative BC-7013.The concentrations of derivative BC-7013 in plasma were determined by high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS /MS) with internal standard method.Plas ma concentration-time profiles of derivative BC-7013 were analyzed by using non-compartmental analysis WinNonlin 5.2 software.
The main pharmacokinetical parameters of i.v.ad ministration were as follows: t1/2β=(1.37 ± 0.14) h, Vd=(1.87 ± 0.25) L·kg-1, AUC(0→∞)=(2.83 ± 0.56) μg·L-1·h, CL=(1.14 ± 0.28) L·h-1·kg-1.The major pharmacokinetical parameters of oral administration were as follows: tmax=(1.94 ± 0.26) h, Cmax=(126.18 ± 6.54) ng·mL-1, AUC(0→∞)=(1.38 ± 0.21) μg·mL-1·h, MRT=(9.49 ± 0.57) h, F=(10.37 ± 1.48) %. The results show that the pharmacokinetical characteristics of pleuromutilin derivative BC-7013 in healthy chicken manifest wide distribution, rapid elimination as well as incomplete absorption and low oral bioavailability.
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