The Effect of Injectio Xiangdan on Endotoxin-Induced Renal DIC in Rabbits

The aim of this research was to study the treatment function and mechanisms of injectio Xiangdan (XD) on endotoxin-induced DIC kidney of rabbits. The DIC kidney model was attained injecting intravenous of Escherichia coli O₁₁₁B₄ endotoxin (ET) solution into the rabbits, then injectio XD to observe its effects on the kidney of rabbits and degradation effects on ET in vivo and in vitro. The results of histopathology showed that the incidence and severity of glomerular microthrombosis, the degeneration and necrosis of epithelia, the formation of tube cast were significantly reduced (P<0.05 or P<0.01) compared to the corresponding model rabbits. The results of limulus agglutination test indicated that injection XD destroyed ET slightly. All above indicated that injectio XD had good prevention effects on endotoxin induced DIC kidney of rabbits, which improved the renal glomerulus capillary blood stream effectively, decreasing the incidence and severity of glomerular thrombosis.Therefore, treatment of the rabbits with XD lessens the degeneration and necrosis of epithelia, the formation of tube cas, maintaining the renal tubules.