Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites

QIN Liuqi; DONG Xianming; SU Xiangyu; ZHOU Wuyi; ZHENG Wenxu

doi:10.7671/j.issn.1001-411X.202106012

Journal of South China Agricultural University > 2022 > 43(1): 37-43. > DOI: 10.7671/j.issn.1001-411X.202106012

QIN Liuqi, DONG Xianming, SU Xiangyu, et al. Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites[J]. Journal of South China Agricultural University, 2022, 43(1): 37-43. DOI: 10.7671/j.issn.1001-411X.202106012

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Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites

QIN Liuqi^{1, 2,},
DONG Xianming^{1, 2},
SU Xiangyu²,
ZHOU Wuyi^{1, 2, ,},
ZHENG Wenxu^{1, 2, ,}

1.
Key laboratory of Bio-based Materials and Energy, Ministry of Education, Guangzhou 510642, China
2.
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China

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Received Date: June 09, 2021
Available Online: May 17, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the feasibility of using bio-based polylactic acid composites to directly construct microporous scaffolds by 3D printing.

Method
Thermogravimetric analyzer and differential scanning calorimeter were used to explore the thermal properties of bio-based polylactic acid composites, scanning electron microscopy was used to characterize the microscopic morphology of the bio-scaffold, and the live/dead cell staining was used for detecting cell adhesion of the scaffold.

Result
The prepared 0.6%ADC-PHAP and 40%NaCl-PHAP composites had good thermal stability and processability, and were suitable for the fused deposition modeling 3D printing process. When the compressive strain was 80%, the corresponding compressive stresses of the 0.6%ADC-PHAP and 40%NaCl-PHAP scaffolds were 45.27 and 52.11 MPa, respectively. The initial decomposition temperature of the 0.6%ADC-PHAP composite was 19.5 ℃ lower than that of the 40%NaCl-PHAP composite. The porosity of the 0.6%ADC-PHAP scaffold reached 63.33% which was conducive to cell adhesion, and the cell compatibility was better than that of the 40%NaCl-PHAP scaffold.

Conclusion
The bio-based polylactic acid composites can be used to directly construct microporous bio-scaffolds through fused deposition modeling 3D printing, and the prepared 0.6%ADC-PHAP bio-scaffold has certain application potential.
- Melt blending,
- 3D printing,
- Scaffold,
- Polylactic acid,
- Bio-based material

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References

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