PHARMACOKINETICS OF FOUR DRUGS IN SWINE

The disposition kinetics of sulfadimidine(SM2),isoniazid(INZ),bromsulphalein(BSP) and phenol-sulfonphthalein (PSP) in normal Swine (n=22,30~39 kg b.w.) were investigated,which was designed to compare with the pharmacokinetics of those drugs in infected Swine.The studies showed that the disposition of SM2 in Swine was characterized with medium distribution volume and low clearance,INZ with high distribution volume and high clearance ,and both BSF and FSP with low distribution volume and high clearance.Such distribution and elimination properties of the drugs determined their concentrations in plasma and half lives in the body,and depended on the elimination capacity of the liver and kidney and the protein-binding of the drugs in the plasma.