Research status and prospect on bacterial 3-oxoacyl-ACP-reductase

3-oxoacyl-ACP-reductase, a member of short chain dehydrogenase/reductase(SDR) super family, participates in the biothsythesis of bacterial fatty acid and derivatives by catalyzing the reduction of 3-oxoacyl-ACP to 3-hydroxyacyl-ACP. 3-oxoacyl-ACP-reductase is ubiquitously exsit in bacterial and highly conversed in amino acid sequence, however, it has diverse biological functions. In this review, we summerize the advance of structures, biological functions and inhibitors of 3-oxoacyl-ACP-reductase in recent years. This paper will provide useful references for further understanding of 3-oxoacyl-ACP-reductase and antibacterial drug design.