Research status and prospect on bacterial 3-oxoacyl-ACP-reductase

WANG Haihong; HU Zhe

doi:10.7671/j.issn.1001-411X.202208055

Journal of South China Agricultural University > 2022 > 43(6): 148-159. > DOI: 10.7671/j.issn.1001-411X.202208055

WANG Haihong, HU Zhe. Research status and prospect on bacterial 3-oxoacyl-ACP-reductase[J]. Journal of South China Agricultural University, 2022, 43(6): 148-159. DOI: 10.7671/j.issn.1001-411X.202208055

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Research status and prospect on bacterial 3-oxoacyl-ACP-reductase

College of Life Sciences, South China Agricultural University/ Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, Guangzhou 510642, China

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Received Date: August 21, 2022
Available Online: May 17, 2023

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Abstract

Abstract

3-oxoacyl-ACP-reductase, a member of short chain dehydrogenase/reductase(SDR) super family, participates in the biothsythesis of bacterial fatty acid and derivatives by catalyzing the reduction of 3-oxoacyl-ACP to 3-hydroxyacyl-ACP. 3-oxoacyl-ACP-reductase is ubiquitously exsit in bacterial and highly conversed in amino acid sequence, however, it has diverse biological functions. In this review, we summerize the advance of structures, biological functions and inhibitors of 3-oxoacyl-ACP-reductase in recent years. This paper will provide useful references for further understanding of 3-oxoacyl-ACP-reductase and antibacterial drug design.
- 3-oxoacyl-ACP-reductase,
- Fatty acid synthesis system II,
- Inhibitor

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