Effect of intrauterine growth retardation on immune organs and plasma cytokine contents in growing-finishing pigs

XIONG Liang; ZHANG Wanghong; YOU Jinming; ZHU Qian; KONG Xiangfeng

doi:10.7671/j.issn.1001-411X.201911028

Journal of South China Agricultural University > 2020 > 41(4): 16-21. > DOI: 10.7671/j.issn.1001-411X.201911028

XIONG Liang, ZHANG Wanghong, YOU Jinming, et al. Effect of intrauterine growth retardation on immune organs and plasma cytokine contents in growing-finishing pigs[J]. Journal of South China Agricultural University, 2020, 41(4): 16-21. DOI: 10.7671/j.issn.1001-411X.201911028

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Effect of intrauterine growth retardation on immune organs and plasma cytokine contents in growing-finishing pigs

1.
Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture,Chinese Academy of Sciences /Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Changsha 410125, China
2.
College of Animal Science and Technology, Jiangxi Agricultural University/ Key Laboratory of Animal Nutrition in Jiangxi Province, Nanchang 330045, China

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Received Date: November 27, 2019
Available Online: May 17, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the effects of intrauterine growth retardation (IUGR) on immune organs and plasma cytokine contents in growing-finishing pigs.

Method
A total of 36 pregnant sows with similar body conditions were selected. After delivery, one IUGR piglet (IUGR group) and one normal born weight piglet (control group) were selected from each litter, respectively. After weaning, the animals were fed with the same basic diet. When the average body weight (BW) of control pigs gained 25, 50 and 100 kg, seven pigs per group were randomly selected to collect blood samples by precaval vein, and plasma cytokine contents were measured. Twelve pigs in each group were killed for isolating and weighing liver, spleen, and kidney to calculate their organ indices.

Result
Compared to the control group with the same BW, the liver, spleen and kidney weights of IUGR pigs decreased by 32.63%, 35.07% and 34.28% at 25 kg BW stage (P<0.01) and decreased by 22.68%, 40.05% and 33.03% at 50 kg BW stage, respectively. The content of plasma interleukin IL-1β in IUGR pigs at 25 and 50 kg BW stages decreased by 20.66% and 27.21% (P<0.05), respectively. Compared to the control group at 50 kg BW stage, the liver index of IUGR pigs increased by 16.25% (P<0.05) and the ratio of IL-1β to IL-10 decreased by 40.67% (P<0.01). Compared to the control group at 100 kg BW stage, the liver index and spleen index of IUGR pigs increased by 10.94% (P<0.05) and 21.74% (P<0.01), respectively, while the liver weight and kidney weight decreased by 13.97% and 17.51% (P<0.01), respectively.

Conclusion
IUGR can alter the organ indices and weights of liver, spleen and kidney, decrease plasma IL-1β content, and therefore influences the immune function in growing-finishing pigs.
- growing-finishing pig,
- intrauterine growth retardation,
- immune organ,
- organ index,
- cytokine

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References

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