Effects of dietary supplementation with lysine and thiazolidinedione on growth performance, serum biochemical parameters and meat quality in finishing pigs

JIN Chenglong; FAN Hongbo; SUI Weiguo; YAN Huichao; WANG Xiuqi; GAO Chunqi

doi:10.7671/j.issn.1001-411X.2017.06.002

Journal of South China Agricultural University > 2017 > 38(6): 9-13. > DOI: 10.7671/j.issn.1001-411X.2017.06.002

JIN Chenglong, FAN Hongbo, SUI Weiguo, YAN Huichao, WANG Xiuqi, GAO Chunqi. Effects of dietary supplementation with lysine and thiazolidinedione on growth performance, serum biochemical parameters and meat quality in finishing pigs[J]. Journal of South China Agricultural University, 2017, 38(6): 9-13. DOI: 10.7671/j.issn.1001-411X.2017.06.002

Citation:

PDF (617 KB)

Effects of dietary supplementation with lysine and thiazolidinedione on growth performance, serum biochemical parameters and meat quality in finishing pigs

College of Animal Science, South China Agricultural University/National Engineering Research Center for Breeding Swine Industry, Guangzhou 510642, China

More Information

Received Date: December 18, 2016
Available Online: May 17, 2023

Graphical Abstract

Abstract

Abstract

Objective
To determine the effects of dietary supplementation with lysine (Lys) and thiazolidinedione(TZD) on growth performance, serum biochemical parameters and meat quality in finishing pigs.

Method
A total of 160 healthy Duroc × Landrace × Large White pigs with similar weight [(92.25±0.91) kg] were randomly divided into four groups with five replicates in each group and eight pigs per replicate (50% males and 50% females). Control group was fed with basic diet (containing 0.85% Lys), experimental group Ⅰ was fed with basic diet and 15 mg·kg^–1 TZD, experimental group Ⅱ was fed with basic diet, extra 0.20% Lys and 15 mg·kg^–1 TZD, experimental group Ⅲ was fed with basic diet, extra 0.40% Lys and 15 mg·kg^–1 TZD. After feeding experiment, the slaughter performance and meat quality were evaluated by selecting one hog from each replicate of the control group and experimental group Ⅲ.

Result
The average daily gain (ADG) enhanced 9.45% in experimental group Ⅲ on day 28 compared with control group (P=0.055). The high-density lipoprotein content in experimental group Ⅲ was 22.81% higher than that in control group (P<0.05) on day 14. The lean percentage anda^* value of longissimus dorsi muscle in experimental group Ⅲ were 7.04% and 4.11% higher compared to control group (P<0.05) on day 28, respectively.

Conclusion
Finishing pigs fed with basic diet supplemented with 0.40% Lys (totally 1.25% Lys) and 15 mg·kg^–1 TZD could increase ADG and lean percentage, and improve meat colour.
- lysine,
- TZD,
- finishing pig,
- growth performance,
- slaughter performance,
- meat quality

FullText(HTML)

References (32)

References

[1]	中华人民共和国国家统计局. 中国统计年鉴: 2015 [DB/OL]. 北京: 中国统计出版社, (2015-10-19) [2016-06-21]. http://www.stats.gov.cn/tjsj/ndsj/2015/indexch.htm.
[2]	刘增金. 基于质量安全的中国猪肉可追溯体系运行机制研究[D]. 北京: 中国农业大学, 2015.
[3]	姜兵. 我国猪肉生产和消费特征及影响因素研究[D]. 江苏: 南京农业大学, 2011.
[4]	CORDERO G, ISABEL B, MENOYO D, et al. Dietary CLA alters intramuscular fat and fatty acid composition of pig skeletal muscle and subcutaneous adipose tissue[J]. Meat Sci, 2010, 85(2): 235-239.
[5]	LI F N, LI L L, YANG H S, et al. Regulation of soy isoflavones on weight gain and fat percentage: Evaluation in a Chinese Guangxi minipig model[J]. Animal, 2011, 5(12): 1903-1908.
[6]	ROSENFELDER P, MOSENTHIN R, SPINDLER H K, et al. Standardized ileal digestibility of amino acids in eight genotypes of soft winter wheat fed to growing pigs[J]. J Anim Sci, 2015, 93(3): 1133-1144.
[7]	ZENG P L, YAN H C, WANG X Q, et al. Effects of dietary lysine levels on apparent nutrient digestibility and serum amino acid absorption mode in growing pigs[J]. Asian-australas J Anim Sci, 2013, 26(7): 1003-1011.
[8]	WANG X Q, ZENG P L, FENG Y, et al. Effects of dietary lysine levels on apparent nutrient digestibility and cationic amino acid transporter mRNA abundance in the small intestine of finishing pigs, Sus scrofa[J]. Anim Sci J, 2012, 83(2): 148-155.
[9]	LI P, ZENG Z, WANG D, et al. Effects of the standardized ileal digestible lysine to metabolizable energy ratio on performance and carcass characteristics of growing-finishing pigs[J]. J Anim Sci Biotechnol, 2012, 3: 9. doi: 10.1186/2049-1891-3-9
[10]	LU Y, YANG X L, LI D F, et al. Effects of the ratio of lysine to digestible energy level in the diet on the expression and activity of transcription factors involved in lipogenesis in Rongchang pigs[J]. J Anim Sci Biotechnol, 2010, 1(3): 165-174.
[11]	ZOU T D, MAO X B, YU B, et al. Effects of dietary energy density and apparent ileal digestible lysine: Digestible energy ratio on growth performance, meat quality, and peroxisome proliferator-activated receptor γ (PPARγ) gene expression of muscle and adipose tissues in Landrace×Rongchang crossbred pigs[J]. Livest Sci, 2014, 167: 219-226.
[12]	MABILLEAU G, CHAPPARD D, BASLÉ M F. Cellular and molecular effects of thiazolidinediones on bone cells: A review[J]. Int J Biochem Mol Biol, 2011, 2(3): 240-246.
[13]	BRUNMAIR B, STANIEK K, LEHNER Z, et al. Lipophilicity as a determinant of thiazolidinedione action in vitro: Findings from BLX-1002, a novel compound with-out affinity to PPARs[J]. Am J Physiol Cell Physiol, 2011, 300(6): C1386-C1392.
[14]	BECK G R JR, KHAZAI N B, BOULOUX G F, et al. The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes[J]. Transl Res, 2013, 161(3): 145-155.
[15]	MACKELLAR J, CUSHMAN S W, PERIWAL V. Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats[J]. PLoS One, 2009, 4(12): e8196.
[16]	BOURAOUI L, CRUZ-GARCIA L, GUTIÉRREZ J, et al. Regulation of lipoprotein lipase gene expression by insulin and troglitazone in rainbow trout (Oncorhynchus mykiss) adipocyte cells in culture[J]. Comp Biochem Physiol A Mol Integr Physiol, 2012, 161(1): 83-88.
[17]	CHEN X, FENG Y, YANG W J, et al. Effects of dietary thiazolidinedione supplementation on growth performance, intramuscular fat and related genes mRNA abundance in the longissimus dorsi muscle of finishing pigs[J]. Asian-australas J Anim Sci, 2013, 26(7): 1012-1020.
[18]	柏美娟, 孔祥峰, 徐海军, 等. 瘦肉型和脂肪型肥育猪胴体性状和肉质的比较研究[J]. 中国畜牧兽医, 2009, 36(6): 178-181.
[19]	KULKARNI A P, SHAHNAWAZ M, ZAHEER Z, et al. Development and validation of a dissolution method for pioglitazone tablets[J]. Dissolut Technol, 2012, 19(4): 36-46.
[20]	MORALES A, GARCÍA H,. Effect of L-lysine on expression of selected genes, serum concentration of amino acids, muscle growth and performance of growing pigs[J]. J Anim Physiol Anim Nutr, 2015, 99(4): 701-709.
[21]	GUAN Y, HAO C, CHA D R, et al. Thiazolidinediones expand body fluid volume through PPAR gamma stimulation of ENaC-mediated renal salt absorption[J]. Nat Med, 2005, 11(8): 861-866.
[22]	MIYAZAKI Y, MAHANKALI A, MASTUDA M, et al. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients[J]. J Clin Endocrinol Metab, 2002, 87(6): 2784-2791.
[23]	LEHRKE M, LAZAR M A. The many faces of PPARγ[J]. Cell, 2005, 123(6): 993-999.
[24]	JING X Y, OU C, CHEN H, et al. Electroacupuncture reduces weight gain induced by rosiglitazone through PPARγ and leptin receptor in CNS[J]. Evid Based Complement Alternat Med, 2016. doi: 10.1155/2016/8098561
[25]	ZHANG H, ZHANG A, KOHAN D E, et al. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention[J]. Proc Natl Acad Sci USA, 2005, 102(26): 9406-9411.
[26]	YASUNARI E, TAKENO K, FUNAYAMA H, et al. Efficacy of pioglitazone on glycemic control and carotid intima-media thickness in type 2 diabetes patients with inadequate insulin therapy[J]. J Diabetes Investig, 2011, 2(1): 56-62.
[27]	BAYS H, MANDARINO L, DEFRONZO R A. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach[J]. J Clin Endocrinol Metab, 2004, 89(2): 463-478.
[28]	BOLER D D, KUTZLER L W, MEEUWSE D M, et al. Effects of increasing lysine on carcass composition and cutting yields of immunologically castrated male pigs[J]. J Anim Sci, 2011, 89(7): 2189-2199.
[29]	JUNG J H, SHIM K S, NA C S, et al. Studies on intramuscular fat percentage in live swine using real-time ultrasound to determine pork quality[J]. Asian-australas J Anim Sci, 2015, 28(3): 318-322.
[30]	郭秀兰, 唐仁勇, 刘达玉, 等. 肌内脂肪对猪肉品质的影响及其营养调控作用[J]. 中国畜牧兽医, 2011, 38(5): 214-217.
[31]	LISTRAT A, LEBRET B, LOUVEAU I, et al. How muscle structure and composition influence meat and flesh quality[J]. The Scientific World J, 2016. doi: 10.1155/2016/3182746
[32]	DASZKIEWICZ T, BAK T, DENABURSKI J. Quality of pork with a different intramuscular fat (IMF) content[J]. Pol J Food Nutr Sci, 2005, 14/55(1): 31-35.

Cited By

Get Citation

PDF

XML

Article views (1633) PDF downloads (1777)

Turn off MathJax

Article Contents

Abstract

References

Effects of dietary supplementation with lysine and thiazolidinedione on growth performance, serum biochemical parameters and meat quality in finishing pigs

Abstract

References

Catalog

Export File

Citation

Format

Content