Injury to immune organs of piglets from three kinds of PRRS vaccine

Objective To study the injury to immune organs of piglets from three kinds of PRRS vaccine(MLV, TJM 92 and JXA-1R vaccines).

Method Fifty new-born healthy piglets were devided into four groups:non-immunized control group(CK group), MLV vaccine group(A group), TJM 92 vaccine group (B group), JXA-1R vaccine group (C group). Every piglit in the experimental group were vaccinated. Then paraffin sections were prepared after pathological anatomy. Changes in percentages of esterase-positive T cells and plasma cells (effector B cells) of different immune organs were summarized by using optimized esterase (α-NAE) and methyl green-pyronin (MG-P) staining.

Result There were significant or highly significant differences in the percentages of esterase-positive T cells and plasma cells of immune organs between each immunized group and CK group.

Conclusion Three kinds of vaccine all have injuries to immune organs of piglets. Injury from JXA-1R vaccine is the strongest, followed by TJM92 vaccine and then MLV vaccine.