Residue depletion of diaveridine in pigs

Objective Determination of diaveridine in pig tissues by high-performance liquid chromatogra phy (HPLC) was carried out.The residue depletion of diaveridine in pigs was investigated after oral ad ministration, and its withdrawal time was estimated.

Method Under routine breeding conditions, thirty healthy pigs were randomly allocated to six treatment groups.All of the pigs were treated with diaverdine at a dosage of 5 mg·kg^-1 twice daily for 7 consecutive days.Five medicated pigs were slaughtered at 6, 24, 96, 168, 240 and 336 h after the last oral administration, and the muscle, liver, kidney and fat tis sues of each pig were sampled.The concentration of diaveridine was analyzed by HPLC.

Result and con clusion Diaveridine in pig tissue was eliminated fast.The concentrations of diaveridine in all tested tis sues dropped below the limit of quantitation (40 μg·kg^-1) at 240 h after the last oral administration. The quickest elimination of diaveridine was observed in muscl whereas the slowest in the kidney.Based on MRLs(50 μg·kg^-1) of diaveridine in poultry tissues, which were regulated by Japan Positive List, the withdrawal time in pigs was analyzed by WT1. 4 software.The results indicate that the withdrawal time of diaveridine should be 8 days in pigs after oral administration.