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    CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
    Citation: CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
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    The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate

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    • The amantadine-resistance of an H5 subtype avian influenza virus(AIV) isolate was characterized.The M gene of AIV 178 isolate was obtained by RT-PCR,and sequence analysis showed that M2 protein contained S31N substitution.Animal trial revealed that the isolate was resistant to the treatment of 200 mg/L amantadine via drinking water.The results suggested that AIV 178 isolate was amantadine resistant,and the position 31 amino acid point mutation in M2 protein may confer the resistance.
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