Abstract: Two hundred specimens of pig liver and one hundred specimens of cattle liver from current Guangzhou market were analysed for hygienic quality by histopathology, histochemistry and ultrastructural routine. Besides bacterial contamination and parasite ovas in liver tissues, twenty-five kinds of lesions were discovered in sixty-eight percent (136/200) of pig livers and seventy-seven percent (77/100) of cattle livers. Besides atrophy and various degeneration of liver cells, edema, cyst, hemorrhage, necrosis and calcification in liver tissues, malignant tumor and pathologic nuclear mitosis in precancer or cancer liver cells were also seen. The research we have done showed that several to more than ten kinds of lesions often occurred in one specimen. The frequency of cirrhosis in these pig and cattle livers was very high. The various lesions described above could influence the nutritional value, hygienic quality,storage and public hygiene of food animal livers.