Abstract: Spodoptera frugiperda is one of the top ten pests in the world, its invasion and damage pose a major threat to agricultural production in China. There are a wide range of hosts for S. frugiperda, and it has been reported to be resistant to a variety of chemical agents and transgenic Bt corn. With increasing resistance to pesticides, the demand for new control methods is becoming more and more necessary. The population genetic control techniques and the methods of disturbing reproductive characteristics of insects were reviewed, including the sex-chain balanced lethal system, building a hybrid infertility balanced lethal line, controlling insect sex, interfering the key genes for insect growth and development and adjusting the proportion of sex pheromone, etc. Based on the reproductive isolation phenomenon of hybrid infertility and mating disorder of two strains (rice & corn) of S. frugiperda, we explored the application prospects of population genetic regulation and reproductive characteristic interference in the control of S. frugiperda. Taking insect reproduction as the entry point, it provides a theoretical basis for the application of insect sterility technology for controlling S. frugiperda.