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    丁唯嘉, 李明哲, 陈泽林, 等. 小菜蛾共生真菌棒曲霉 XCE02的代谢产物及抗菌活性[J]. 华南农业大学学报, 2020, 41(2): 76-81. doi: 10.7671/j.issn.1001-411X.201904034
    引用本文: 丁唯嘉, 李明哲, 陈泽林, 等. 小菜蛾共生真菌棒曲霉 XCE02的代谢产物及抗菌活性[J]. 华南农业大学学报, 2020, 41(2): 76-81. doi: 10.7671/j.issn.1001-411X.201904034
    shu
    DING Weijia, LI Mingzhe, CHEN Zelin, et al. Metabolites of a symbiotic fungus Aspergillus clavatus XCE02 from Plutella xylostella and their antifungal activities[J]. Journal of South China Agricultural University, 2020, 41(2): 76-81. doi: 10.7671/j.issn.1001-411X.201904034
    Citation: DING Weijia, LI Mingzhe, CHEN Zelin, et al. Metabolites of a symbiotic fungus Aspergillus clavatus XCE02 from Plutella xylostella and their antifungal activities[J]. Journal of South China Agricultural University, 2020, 41(2): 76-81. doi: 10.7671/j.issn.1001-411X.201904034
    shu

    小菜蛾共生真菌棒曲霉 XCE02的代谢产物及抗菌活性

    Metabolites of a symbiotic fungus Aspergillus clavatus XCE02 from Plutella xylostella and their antifungal activities

      摘要
    • 摘要:
      目的  研究小菜蛾共生真菌棒曲霉Aspergillus clavatus XCE02代谢产物及其抗植物病原真菌的活性。
      方法  柱层析技术分离纯化XCE02代谢产物，并运用波谱技术鉴定结构；滤纸片扩散法测试代谢产物对香蕉炭疽菌和小麦赤霉菌的抑菌活性。
      结果  分离鉴定出gliomasolide A、Sch725674、gliomasolide C、clavatustide A、clavatustide B、20−羟基麦角甾−4，6，8(14)，22−四烯−3−酮、黄嘌呤、麦角甾醇、过氧化麦角甾醇和丁二酸10个化合物。在250 μg/mL时，gliomasolide A、Sch725674和gliomasolide C对香蕉炭疽菌和小麦赤霉菌显示了高度抗菌活性，clavatustide A和clavatustide B对香蕉炭疽菌和小麦赤霉菌显示了中度抗菌活性，20−羟基麦角甾−4，6，8(14)，22−四烯−3−酮对小麦赤霉菌显示了中度抗菌活性。
      结论  从曲霉属分离到了gliomasolide A、gliomasolide C和20−羟基麦角甾−4，6，8(14)，22−四烯−3−酮，gliomasolide A、Sch725674和gliomasolide C可作为相应抗菌农药先导化合物开展深入研究。

       

      Abstract:
      Objective  To study the metabolites of a symbiotic fungus Aspergillus clavatus XCE02 from Plutella xylostella and their antifungal activities against plant pathogens.
      Method  The metabolites were isolated and purified by column chromatography. Their structures were elucidated by spectral analysis. The antifungal activities of the metabolites against Colletotrichum musae and Fusarium graminearum were investigated using paper disc-agar diffusion method.
      Result  Ten compounds were isolated and identified as gliomasolide A, Sch725674, gliomasolide C, clavatustide A, clavatustide B, 20-hydroxyergosta-4, 6, 8(14), 22-tetraen-3-one, xanthine, ergosterol, ergosterol peroxide and butanedioic acid. At the concentration of 250 μg/mL, gliomasolide A, Sch725674 and gliomasolide C exhibited high inhibitory activities against C. musae and F. graminearum, clavatustide A and clavatustide B showed moderate inhibitory activities against C.musae and F.graminearum and 20-hydroxyergosta-4, 6, 8(14), 22-tetraen-3-one showed moderate inhibitory activity against F.graminearum.
      Conclusion  Gliomasolide A, gliomasolide C and 20-hydroxyergosta-4, 6, 8(14), 22-tetraen-3-one have been obtained from the genus Aspergillus in this study. Gliomasolide A, Sch725674 and gliomasolide C can be used as leading compounds for developing antifungal pesticide.

       

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