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    江丹莉, 劳永聪, 吴纯华, 等. 外源性褪黑素和脂多糖对育成期山麻鸭生长及免疫功能的影响[J]. 华南农业大学学报, 2018, 39(5): 47-52. doi: 10.7671/j.issn.1001-411X.2018.05.007
    引用本文: 江丹莉, 劳永聪, 吴纯华, 等. 外源性褪黑素和脂多糖对育成期山麻鸭生长及免疫功能的影响[J]. 华南农业大学学报, 2018, 39(5): 47-52. doi: 10.7671/j.issn.1001-411X.2018.05.007
    shu
    JIANG Danli, LAO Yongcong, WU Chunhua, WANG Jinhui, BAO Haiyuan, LIN Zetong, ZHANG Beibei, LIN Danmin, LAO Jiawei, HUANG Yunmao. Effects of exogenous melatonin and lipopolysaccharide on the growth and immune function of Shanma ducks[J]. Journal of South China Agricultural University, 2018, 39(5): 47-52. DOI: 10.7671/j.issn.1001-411X.2018.05.007
    Citation: JIANG Danli, LAO Yongcong, WU Chunhua, WANG Jinhui, BAO Haiyuan, LIN Zetong, ZHANG Beibei, LIN Danmin, LAO Jiawei, HUANG Yunmao. Effects of exogenous melatonin and lipopolysaccharide on the growth and immune function of Shanma ducks[J]. Journal of South China Agricultural University, 2018, 39(5): 47-52. DOI: 10.7671/j.issn.1001-411X.2018.05.007
    shu

    外源性褪黑素和脂多糖对育成期山麻鸭生长及免疫功能的影响

    Effects of exogenous melatonin and lipopolysaccharide on the growth and immune function of Shanma ducks

      摘要
    • 摘要:
      目的  研究外源性褪黑素(MLT)和脂多糖(LPS)对鸭生长性能及免疫功能的影响。
      方法  随机选用80只28日龄健康山麻鸭，平均分成4组，包括对照组、MLT组、MLT+LPS组和LPS组。试验过程中测定山麻鸭体质量和采食量，并于试验最后一天(第50天)进行采样和采血测定生化、生长相关激素等指标。
      结果  与对照组相比，LPS降低了山麻鸭生长性能，MLT提高了山麻鸭生长性能，但差异不显著(P>0.05)；LPS使血清中胰岛素样生长因子、甲状腺素水平下降(P>0.05)，MLT显著提高了血清生长激素、胰岛素样生长因子和甲状腺素水平(P<0.05)；LPS使胸腺指数下降、脾脏指数上升(P<0.01)。观察组织切片发现，LPS使胸腺、肝脏和脾脏出现一定程度的损伤，而MLT组无明显损伤；LPS显著提高了血清谷草转氨酶活性(P<0.05)，MLT显著降低了谷草转氨酶活性(P<0.05)，提高了血清白蛋白含量(P>0.05)。
      结论  LPS降低山麻鸭生长性能和免疫功能，MLT对LPS刺激引起的生长缓慢和免疫功能下降等机体损伤起到缓解作用。

       

      Abstract:
      Objective  To investigate the effects of exogenous melatonin (MLT) and lipopolysaccharide (LPS) on the growth performance and immune function of ducks.
      Method  Eighty 28-day-old healthy Shanma ducks were randomly chosen and divided into four groups including control, MLT, MLT+LPS and LPS groups. The weight and food intake were measured throughout the experimental duration, and on the last day (the 50th day), organism and blood samples were collected to measure biochemical indexes and the levels of growth hormones.
      Result  Compared with control, LPS impaired growth performance of ducks while MLT had the opposite effect, but the difference was not significant (P>0.05). The levels of insulin-like growth factor and thyroxine in serum declined in LPS group (P>0.05), while the levels of serum growth hormone, insulin-like growth factor and thyroxine increased significantly in MLT group (P<0.05). LPS decreased the thymus index and raised the spleen index significantly (P<0.01). By observing tissue sections, a certain degree of damage was found in thymus, liver and spleen of LPS group, while MLT group had no obvious damage. LPS elevated AST content in serum significantly. MLT significantly lowered AST content (P<0.05) but elevated albumin content in serum (P>0.05).
      Conclusion  LPS impairs the growth performance and immune function of ducks, and MLT relieves the harmful effects such as slow growth and immunity decline caused by LPS.

       

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