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    李文生, 周丹丽, 陆盈池, 钟浩然, 朱新伟, 丁唯嘉, 李春远. 1株红树内生真菌Fusarium sp.代谢产物的研究[J]. 华南农业大学学报, 2017, 38(3): 64-69. DOI: 10.7671/j.issn.1001-411X.2017.03.011
    引用本文: 李文生, 周丹丽, 陆盈池, 钟浩然, 朱新伟, 丁唯嘉, 李春远. 1株红树内生真菌Fusarium sp.代谢产物的研究[J]. 华南农业大学学报, 2017, 38(3): 64-69. DOI: 10.7671/j.issn.1001-411X.2017.03.011
    shu
    LI Wensheng, ZHOU Danli, LU Yingchi, ZHONG Haoran, ZHU Xinwei, DING Weijia, LI Chunyuan. Study on the metabolites of a mangrove endophytic fungus Fusarium sp.[J]. Journal of South China Agricultural University, 2017, 38(3): 64-69. DOI: 10.7671/j.issn.1001-411X.2017.03.011
    Citation: LI Wensheng, ZHOU Danli, LU Yingchi, ZHONG Haoran, ZHU Xinwei, DING Weijia, LI Chunyuan. Study on the metabolites of a mangrove endophytic fungus Fusarium sp.[J]. Journal of South China Agricultural University, 2017, 38(3): 64-69. DOI: 10.7671/j.issn.1001-411X.2017.03.011
    shu

    1株红树内生真菌Fusarium sp.代谢产物的研究

    Study on the metabolites of a mangrove endophytic fungus Fusarium sp.

      摘要
    • 摘要:
      目的 研究红树林镰刀菌属真菌Fusarium sp.R5的代谢产物。
      方法 采用硅胶柱层析分离纯化代谢产物，波谱技术鉴定结构，滤纸片扩散法测试抗植物病原真菌活性。
      结果 分离鉴定5-羟甲基-2-呋喃甲醛（化合物1），(3R, 4R)-顺-4-羟基蜂蜜曲菌素（化合物2），(3R, 4R)-顺-4, 7-二羟基蜂蜜曲菌素（化合物3），Clavatol（化合物4），酒渣碱（化合物5），麦角甾-4, 6, 8(14), 22-四烯-3酮（化合物6）, β-谷甾醇（化合物7）、3β-胆甾-5-烯-3-醇（化合物8）、丁二酸和顺丁烯二酸10个化合物。在250 μg·mL-1时，化合物5对香蕉炭疽菌Colletotrichum musae高度抗菌，化合物5和6对番茄枯萎菌F. oxysporum、小麦赤霉菌F. graminearum中度抗菌。
      结论 从Fusarium属分离得到化合物1~8, 其中，化合物5、6可作为相应农药抗菌先导化合物开展深入研究。

       

      Abstract:
      Objective To study the metabolites of a mangrove fungus Fusarium sp. R5.
      Method The fermented filtrate of R5 fungus was isolated by silica gel column chromatography. The structures of the metabolites were characterized by spectral analyses. The antifungal activities were investigated using the paper disc-agar diffusion method.
      Result Ten compounds were isolated and identified as 5-hydroxymethyl-2-furaldehyde (compound 1), (3R, 4R)-cis-4-hydroxymellein (compound 2), (3R, 4R)-cis-4, 7-dihydroxymellein (compound 3), clavatol (compound 4), flazine (compound 5), ergosta-4, 6, 8(14), 22-tetraen-3-one (compound 6), β-sitosterol (compound 7), 3β-cholest-5-en-3-ol (compound 8), butanedioic acid and maleic acid. At the concentration of 250 μg·mL-1, compound 5 showed high inhibitory activity against Colletotrichum musae (Berk.&M. A. Curtis) Arx., compounds 5 and 6 showed moderate inhibitory activity against F. oxysporum and F. graminearum Schw.
      Conclusion Compounds 1~8 are isolated from Fusarium sp. and among them, compounds 5 and 6 could be used as the lead compounds in antifungal agents.

       

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