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    郭红燕, 周连根, 钟佳莲, 孙美珍, 梁超平, 黄显会, 曾振灵. 二甲氧苄啶在猪体内的残留消除[J]. 华南农业大学学报, 2015, 36(4): 32-35. DOI: 10.7671/j.issn.1001-411X.2015.04.006
    引用本文: 郭红燕, 周连根, 钟佳莲, 孙美珍, 梁超平, 黄显会, 曾振灵. 二甲氧苄啶在猪体内的残留消除[J]. 华南农业大学学报, 2015, 36(4): 32-35. DOI: 10.7671/j.issn.1001-411X.2015.04.006
    shu
    GUO Hongyan, ZHOU Liangen, ZHONG Jialian, SUN Meizhen, LIANG Chaoping, HUANG Xianhui, ZENG Zhenling. Residue depletion of diaveridine in pigs[J]. Journal of South China Agricultural University, 2015, 36(4): 32-35. DOI: 10.7671/j.issn.1001-411X.2015.04.006
    Citation: GUO Hongyan, ZHOU Liangen, ZHONG Jialian, SUN Meizhen, LIANG Chaoping, HUANG Xianhui, ZENG Zhenling. Residue depletion of diaveridine in pigs[J]. Journal of South China Agricultural University, 2015, 36(4): 32-35. DOI: 10.7671/j.issn.1001-411X.2015.04.006
    shu

    二甲氧苄啶在猪体内的残留消除

    Residue depletion of diaveridine in pigs

      摘要
    • 摘要:
      目的 建立在猪组织中二甲氧苄啶浓度的检测方法，并对二甲氧苄啶在猪体内的残留消除进行研究，制订该药在猪体内的休药期.
      方法 常规饲养条件下，将30头健康猪随机分为6组，按体质量以5 mg·kg-1剂量混饲给药，每天2次，连用7 d，于最后一次给药后6、24、96、168、240和336 h各宰杀1组猪，分别采集每头猪的肌肉、肝脏、肾脏和脂肪组织，采用HPLC法对二甲氧苄啶在各组织的残留量进行测定.
      结果和结论 二甲氧苄啶在猪组织中消除较快，给药后第240小时所有检测组织中的二甲氧苄啶已全部低于方法的定量限(40 μg·kg-1)，二甲氧苄啶在肌肉中消除最快，在肾脏中消除最慢.根据日本肯定列表规定的二甲氧苄啶在禽组织的最大残留限量(50 μg·kg-1)和WT1. 4休药期软件计算结果，建议该药在猪体内的休药期为8 d.

       

      Abstract:
      Objective Determination of diaveridine in pig tissues by high-performance liquid chromatogra phy (HPLC) was carried out.The residue depletion of diaveridine in pigs was investigated after oral ad ministration, and its withdrawal time was estimated.
      Method Under routine breeding conditions, thirty healthy pigs were randomly allocated to six treatment groups.All of the pigs were treated with diaverdine at a dosage of 5 mg·kg-1 twice daily for 7 consecutive days.Five medicated pigs were slaughtered at 6, 24, 96, 168, 240 and 336 h after the last oral administration, and the muscle, liver, kidney and fat tis sues of each pig were sampled.The concentration of diaveridine was analyzed by HPLC.
      Result and con clusion Diaveridine in pig tissue was eliminated fast.The concentrations of diaveridine in all tested tis sues dropped below the limit of quantitation (40 μg·kg-1) at 240 h after the last oral administration. The quickest elimination of diaveridine was observed in muscl whereas the slowest in the kidney.Based on MRLs(50 μg·kg-1) of diaveridine in poultry tissues, which were regulated by Japan Positive List, the withdrawal time in pigs was analyzed by WT1. 4 software.The results indicate that the withdrawal time of diaveridine should be 8 days in pigs after oral administration.

       

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