高级检索
    雷红涛,沈玉栋,刘文字,邱志超,杨瑾,孙远明. 甲硝唑半抗原及全抗原合成与鉴定[J]. 华南农业大学学报, 2007, 28(3): 101-104. DOI: 10.7671/j.issn.1001-411X.2007.03.023
    引用本文: 雷红涛,沈玉栋,刘文字,邱志超,杨瑾,孙远明. 甲硝唑半抗原及全抗原合成与鉴定[J]. 华南农业大学学报, 2007, 28(3): 101-104. DOI: 10.7671/j.issn.1001-411X.2007.03.023
    shu
    LEI Hong-tao,SHEN Yu-dong,LIU Wen-zi,QIU Zhi-chao,YANG Jin,SUN Yuan-ming. Synthesis and Identification of the Hapten and Complete Antigen of Metronidazole[J]. Journal of South China Agricultural University, 2007, 28(3): 101-104. DOI: 10.7671/j.issn.1001-411X.2007.03.023
    Citation: LEI Hong-tao,SHEN Yu-dong,LIU Wen-zi,QIU Zhi-chao,YANG Jin,SUN Yuan-ming. Synthesis and Identification of the Hapten and Complete Antigen of Metronidazole[J]. Journal of South China Agricultural University, 2007, 28(3): 101-104. DOI: 10.7671/j.issn.1001-411X.2007.03.023
    shu

    甲硝唑半抗原及全抗原合成与鉴定

    Synthesis and Identification of the Hapten and Complete Antigen of Metronidazole

      摘要
    • 摘要: 在微波加热条件下,将甲硝唑与琥珀酸酐反应,合成半抗原甲硝唑半琥珀酸酯,氢核磁共振、电喷雾质谱、红外光谱方法的鉴定结果表明,目标半抗原合成成功;通过活泼酯法将半抗原与载体蛋白偶联制备甲硝唑全抗原,紫外光谱法鉴定结果表明,全抗原合成成功.

       

      Abstract: The hapten metronidazole monosuccinate was synthesized by reacting metronidazole and succinic anhydride under microwave heating. Identification using 1^H nuclear magnetic resonance, electrospray ionization mass and infrared spectrum showed the hapten was successfully synthesized. Then active ester method was used to produce complete antigen of metronidazole, which was confirmed by analysis using ultraviolet spectrum.

       

      • HTML全文
      • 参考文献(0)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回