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    曹伟胜,徐成刚,任涛,罗开健,张桂红,廖明. H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定[J]. 华南农业大学学报, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
    引用本文: 曹伟胜,徐成刚,任涛,罗开健,张桂红,廖明. H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定[J]. 华南农业大学学报, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
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    CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
    Citation: CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
    shu

    H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定

    The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate

      摘要
    • 摘要: 对1株H5亚型禽流感病毒（AIV）分离株进行了金刚烷胺耐药性的鉴定．应用RT—PCR获得了AIV178株的M基因，序列分析显示M2蛋白有S31N的点突变；动物试验发现该毒株对200mg／L金刚烷胺饮水途径给药仍有抗性．结果表明AIV178分离株具有对金刚烷胺的耐药性，而且M2蛋白的第31位氨基酸突变可能与此有关．

       

      Abstract: The amantadine-resistance of an H5 subtype avian influenza virus(AIV) isolate was characterized.The M gene of AIV 178 isolate was obtained by RT-PCR,and sequence analysis showed that M2 protein contained S31N substitution.Animal trial revealed that the isolate was resistant to the treatment of 200 mg/L amantadine via drinking water.The results suggested that AIV 178 isolate was amantadine resistant,and the position 31 amino acid point mutation in M2 protein may confer the resistance.

       

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