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H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定

曹伟胜,徐成刚,任涛,罗开健,张桂红,廖明

曹伟胜,徐成刚,任涛,罗开健,张桂红,廖明. H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定[J]. 华南农业大学学报, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
引用本文: 曹伟胜,徐成刚,任涛,罗开健,张桂红,廖明. H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定[J]. 华南农业大学学报, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021
Citation: CAO Wei-sheng,XU Cheng-gang,REN Tao,LUO Kai-jian,ZHANG Gui-hong,LIAO Ming. The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate[J]. Journal of South China Agricultural University, 2006, 27(4): 82-85. DOI: 10.7671/j.issn.1001-411X.2006.04.021

H5亚型禽流感病毒分离株对金刚烷胺耐药性的鉴定

基金项目: 广东省自然科学基金;国家科技攻关项目;广东省自然科学基金

The Identification of Amantadine-Resistance of an H5 Subtype Avian Influenza Virus Isolate

  • 摘要: 对1株H5亚型禽流感病毒(AIV)分离株进行了金刚烷胺耐药性的鉴定.应用RT—PCR获得了AIV178株的M基因,序列分析显示M2蛋白有S31N的点突变;动物试验发现该毒株对200mg/L金刚烷胺饮水途径给药仍有抗性.结果表明AIV178分离株具有对金刚烷胺的耐药性,而且M2蛋白的第31位氨基酸突变可能与此有关.
    Abstract: The amantadine-resistance of an H5 subtype avian influenza virus(AIV) isolate was characterized.The M gene of AIV 178 isolate was obtained by RT-PCR,and sequence analysis showed that M2 protein contained S31N substitution.Animal trial revealed that the isolate was resistant to the treatment of 200 mg/L amantadine via drinking water.The results suggested that AIV 178 isolate was amantadine resistant,and the position 31 amino acid point mutation in M2 protein may confer the resistance.
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出版历程
  • 收稿日期:  2006-04-19
  • 刊出日期:  2006-10-09

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