Abstract: To study the epidemiology of pseudorabies(PR),the investigation of temporal and spatial distribution of pseudorabies(PR)were conducted in Guangdong Province from 1998 to 2004.The seropositive rates of PR were higher(>20%) in Dongguan,Huizhou,Shenzhen,Yangjiang,Zhuhai,and lower(<10%) in Qingyuan and Shantou.The highest was 3.82 times as much as the lowest.The seropositive rates of 51.7% pig farms were less than 10%.In temporal distribution,a peak of PR seroprevalence may appear every 5 months.Forecast by ARIMA model revealed that seropositive rate in Jan 2005 may be 14.23% approaching the true value 15.06%.Analysis of spatial-temporal correspondence showed that the high seroprevalence of PR for Pearl River Delta appeared in 2002 and 2003,for the north in 2001.In 2002 and 2003,the low seroprevalence of PR were observed in the east.Two-dimension chart covered 83.3% original information.