Abstract: The nucleus base was composed of 281 sows and 35 heritage boars imported from DGI Company of Canada in 2006. The open systematic breeding method was used with proper introduction of superior boar semen. Growth and development performances were tested during the improvement period. The Best Linear Unbiased Prediction (BLUP) method, Molecule Maker Selection and Genomic Selection were integrated and implemented. The specialized line S22 was obtained after eight years of breeding. This line S22 possessed the characters of high and long body, fast growth, high feed converse efficiency and no stressed halothane gene. This line was a suitable sire line for producing high weight slaughter pigs.