摘要:
取健康杂种猪7头(37.1±2.9ks),人工复材猪链球菌病,探讨本病在发生和发展过程中动物血液成分的变化规律,每猪在皮下接种猪链球菌12.5亿(活菌数)后第5和10天,血液出现以出血性贫血、低血浆蛋白血症和高白细胞血症为特征的病理变化,且并发血沉速率和血小板数升高等反应,虽然发病过程中病猪血中的淋巴细胞和嗜中性细胞的比例无明显变化,但淋巴细胞中的T-细胞明显减少,B-细胞明显增加,活细胞数显著减少,死细胞数显著升高(p<0.05),白细胞的这些变化与机体的免疫反应相关联,颇具特征,从接种后第9天起,连续6天、每天两次给动物静注磺胺二甲嘧啶+TMP,能明显改善患猪的血液学状况,提高机体的抵抗力,使动物得到康复。本研究对阐明机体、病原和药物三者之间的关系有参考意义。
Abstract:
In order to investigate how blood compositions are changed by contagious diseases,7 hybrid pigs were infected by inoculating each with 1.25 billion live Streptococcus suis Subcutaneously.Severe hematological changes could be observed at 5 and 10 days after inoculation,which was characterized by hemorrhagic anemia ,hypoproteinenvia and hyperleukocytosis,and accompanied by high erythrocyte sedimentation rate and incresed munber of blood platelets.Among lymphocytes,T-and living cells decreased,and B-and dead cells increased signifificantly,although there was no marked change in the proportion of lymphocytes to neutrophilic cells in the blood of infected animals.Intravenous injections of sulfadimidne +trimethoprim to infected animals continously for 6 days (twice a day) from the 9th day after infection ,were able to improve the hematological and immunological picture significantly and make the animals recover.The interactions among animals,bacteria and therapeutic agents are discussed.
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