四种药物在猪的药动学特征

基金项目: 国家自然科学基金

PHARMACOKINETICS OF FOUR DRUGS IN SWINE

摘要: 为给疾病动物的药动学研究作准备,本文研究磺胺二甲嘧啶(SM_2)、异烟肼(ISZ)、磺溴酞(BSP)和酚磺酞(PSP)在猪(n=22,30～39 kg)的动态特征,结果表明,在猪体内,SM_2以中分布、低清除,INZ以高分布、高清除,BSP和PSP则以低分布、高清除为特征,药物的这些分布和消除特征直接影响药物在血中的浓度和在体内的滞留时间,而这些特征又是由机体的主要消除器官肝脏和肾脏对药物的消除能力以及药物与血浆蛋白的结合程度所决定。
- 猪 /
- 异烟肼 /
- 磺溴酞 /
- 药物动力学
Abstract: The disposition kinetics of sulfadimidine(SM2),isoniazid(INZ),bromsulphalein(BSP) and phenol-sulfonphthalein (PSP) in normal Swine (n=22,30~39 kg b.w.) were investigated,which was designed to compare with the pharmacokinetics of those drugs in infected Swine.The studies showed that the disposition of SM2 in Swine was characterized with medium distribution volume and low clearance,INZ with high distribution volume and high clearance ,and both BSF and FSP with low distribution volume and high clearance.Such distribution and elimination properties of the drugs determined their concentrations in plasma and half lives in the body,and depended on the elimination capacity of the liver and kidney and the protein-binding of the drugs in the plasma.
- pharmacokinetics /
- Swine /
- Sulfadimidine /
- Isonlazid /
- Bromaulphalein /
- Phenolsulfonphthalein