Abstract: The secretory cavity is a ubiquitous structure in Citrus plants, which is the main place for the synthesis and accumulation of medicinal components. Current studies have shown that the secretory cavity of citrus plants occurs in schizolysogenesis, and the development of secretory cells is a process of programmed cell death. However, the study of the development of secretory cavity has experienced a hundred years. This review focuses on the origin, development and programmed cell death of secretory cavity in Citrus, in order to provide a reference for future studies on secretory cavity morphogenesis.