生物基聚乳酸复合材料3D打印制备含微孔支架及性能研究

    Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites

    • 摘要:
      目的  探讨生物基聚乳酸复合材料用于3D打印直接构建含微孔支架的可行性。
      方法  采用热重分析仪和差示扫描量热仪探究聚乳酸复合材料的热性能,扫描电镜表征支架的微观形貌,活/死细胞染色检测支架的细胞黏附情况。
      结果  所制备的0.6%ADC-PHAP和40%NaCl-PHAP复合材料具有良好的热稳定性和加工性,适用于熔融沉积3D打印。当压缩应变为80%时,0.6%ADC-PHAP和40%NaCl-PHAP支架相应的压缩应力分别为45.27和52.11 MPa;0.6%ADC-PHAP复合材料的初始分解温度比40%NaCl-PHAP复合材料低19.5 ℃;0.6%ADC-PHAP支架的孔隙率达到63.33%,有利于细胞黏附,且细胞相容性比40%NaCl-PHAP支架更好。
      结论  生物基聚乳酸复合材料可通过熔融沉积型3D打印直接构建含微孔支架,所制备的0.6%ADC-PHAP支架具有一定的应用潜力。

       

      Abstract:
      Objective  To explore the feasibility of using bio-based polylactic acid composites to directly construct microporous scaffolds by 3D printing.
      Method  Thermogravimetric analyzer and differential scanning calorimeter were used to explore the thermal properties of bio-based polylactic acid composites, scanning electron microscopy was used to characterize the microscopic morphology of the bio-scaffold, and the live/dead cell staining was used for detecting cell adhesion of the scaffold.
      Result  The prepared 0.6%ADC-PHAP and 40%NaCl-PHAP composites had good thermal stability and processability, and were suitable for the fused deposition modeling 3D printing process. When the compressive strain was 80%, the corresponding compressive stresses of the 0.6%ADC-PHAP and 40%NaCl-PHAP scaffolds were 45.27 and 52.11 MPa, respectively. The initial decomposition temperature of the 0.6%ADC-PHAP composite was 19.5 ℃ lower than that of the 40%NaCl-PHAP composite. The porosity of the 0.6%ADC-PHAP scaffold reached 63.33% which was conducive to cell adhesion, and the cell compatibility was better than that of the 40%NaCl-PHAP scaffold.
      Conclusion  The bio-based polylactic acid composites can be used to directly construct microporous bio-scaffolds through fused deposition modeling 3D printing, and the prepared 0.6%ADC-PHAP bio-scaffold has certain application potential.

       

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