非编码RNAs调控家禽骨骼肌生长发育的表观遗传机制研究进展

    Research progress of epigenetic mechanism of noncoding RNAs regulating avian skeletal muscle development

    • 摘要: 肉、蛋、奶是畜牧业最主要的三大产品,其中,肉的需求量是最高的。肌肉是动物躯体的重要组成部分,仅骨骼肌就已占全身体质量的40%左右。骨骼肌在调节动物新陈代谢、机体运动、能量储存和健康等方面至关重要,是机体功能正常运转的必要组分。骨骼肌发育过程极其复杂,主要包括体节细胞增殖分化、成肌细胞增殖分化、肌管成熟以及肌纤维形成等环节,整个过程受许多遗传因子调控,其中,由微小RNAs(miRNAs)、长链非编码RNAs(lncRNAs)、环状RNAs(circRNAs)等几种类型构成的非编码RNAs(ncRNAs)可以通过靶向关键因子调控骨骼肌发育过程。本文介绍了各类ncRNAs的特征与功能,总结了近年来有关ncRNAs在家禽肌肉生长发育中的研究,阐述ncRNAs在骨骼肌生长发育进程中的表观遗传调控机制,为改善家禽生长发育提供参考。

       

      Abstract: Meat, eggs and milk are three important products in animal husbandry, among which, the demand for meat is the highest. Muscle is an essential component of animal body, and skeletal muscle accounts for about 40% of body weight. Skeletal muscle plays an important role in animal metabolism, body movement, energy storage and health, and it's the essential part in body function normal running. The development process of skeletal muscle is extremely complex, mainly including somite proliferation and differentiation, myoblast proliferation and differentiation, myotube fusion, and the formation of muscle fiber, and the whole progress is regulated by many genetic factors. Non-coding RNAs (ncRNAs), which mainly consist of micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), can regulate skeletal muscle development by targeting key factors. This paper briefly described the characteristics and functions of those ncRNAs, then reviewed recent studies of ncRNAs in avian muscle growth and development, and elucidated the epigenetic regulatory mechanism of ncRNAs in skeletal muscle growth and development, which could provide references for improving avian growth and development.

       

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