谢青梅,徐维加,陈俊伟,王玲玲,马静云,毕英佐,曹永长. H5亚型禽流感病毒血凝素蛋白单克隆抗体的制备及鉴定[J]. 华南农业大学学报, 2007, 28(4): 117-118. DOI: 10.7671/j.issn.1001-411X.2007.04.028
    引用本文: 谢青梅,徐维加,陈俊伟,王玲玲,马静云,毕英佐,曹永长. H5亚型禽流感病毒血凝素蛋白单克隆抗体的制备及鉴定[J]. 华南农业大学学报, 2007, 28(4): 117-118. DOI: 10.7671/j.issn.1001-411X.2007.04.028
    XIE Qing-mei,XU Wei-jia,CHEN Jun-wei,WANG Ling-ling,MA Jing-yun,BI Ying-zuo,CAO Yong-chang. Preparation and Identification of Monoclonal Antibodies Against Haemagglutinin of Subtype H5 Avian Influenza Virus[J]. Journal of South China Agricultural University, 2007, 28(4): 117-118. DOI: 10.7671/j.issn.1001-411X.2007.04.028
    Citation: XIE Qing-mei,XU Wei-jia,CHEN Jun-wei,WANG Ling-ling,MA Jing-yun,BI Ying-zuo,CAO Yong-chang. Preparation and Identification of Monoclonal Antibodies Against Haemagglutinin of Subtype H5 Avian Influenza Virus[J]. Journal of South China Agricultural University, 2007, 28(4): 117-118. DOI: 10.7671/j.issn.1001-411X.2007.04.028

    H5亚型禽流感病毒血凝素蛋白单克隆抗体的制备及鉴定

    Preparation and Identification of Monoclonal Antibodies Against Haemagglutinin of Subtype H5 Avian Influenza Virus

    • 摘要: 用纯化的H5亚型禽流感病毒(AIV)抗原免疫Balb/C小鼠,取免疫小鼠脾细胞与SP2/0骨髓瘤细胞融合,经筛选,获得9株稳定分泌单克隆抗体的杂交瘤细胞株,其中4株能高效分泌血凝素(HA)蛋白特异性的单克隆抗体.特异性试验表明,IE6单克隆抗体仅与试验的H5病毒株反应,而不与新城疫病毒(NDV)、H9亚型AIV和产蛋下降综合症病毒(EDSV)反应.这9株单克隆抗体分别为IgG1、IgG2a、IgG2b、IgM亚类,κ轻链.

       

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