Abstract: The chemical stability and antioxidative activity of the two kinds of watersoluble pigment material extracted from Japanese red Perilla and local Perilla were investigated. The results showed that the chemical properties of two kinds of Perillas were quite different; Pigment stability of Japanese red Perilla to heat and light was better than that of local Perilla. Both of antioxidative activity and contents of polyphenol and pigment of Japanese red Perilla are higher than that of local Perilla. There was a significant correlation between the antioxidative activity of Perillas and the level of contents of polyphenol and pigment. It was proved that there was a direct contribution of polyphenol and pigment in antioxidative activity of Perillas.